2-溴-4-甲基苯酚的合成

Synthesis of 2-Bromo-4-methylphenol

以对甲基苯酚为原料经过酯化、溴化和水解等步骤合成了 2 -溴 - 4-甲基苯酚 ,平均产率为85 .6% ,并通过红外光谱和核磁共振谱对产物结构进行了确证。溴化反应最佳条件为 :反应温度为- 5°C,溶液的 p H值为 7,反应时间为 5 h,搅拌速度为 1 2 0 0 r/ min。

Bromo 4 methylphenol was synthesized from 4 methylphenol by esterification, bromination and hydrolysis, and the yield was 85.6% . The product was characterized by IR and 1H NMR spectroscopy. The optimum conditions of bromination reaction were: reaction temperature -5 °C , pH of solution 7, reaction time 5 h and agitation rate 1200 r/min.