DPOAE检测在鼻咽癌患者放疗后内耳损伤研究中的应用

Cochlea Radioative Injury after Radiotherapy for Nasopharyngeal Carcinoma with Distortion Product Otoacoustic Emission

【目的】探讨畸变产物耳声发射 (DPOAE)早期发现鼻咽癌放疗后耳蜗功能损害的价值。【方法】利用Capella型耳声发射分析仪在放疗前、放疗中、放疗结束时、放疗后 6个月和放疗后 12个月对鼻咽癌患者的 4 0例耳行DPOAE测试 ,观察其不同频率幅值的变化 ,并与纯音测听的骨导听阈比较。【结果】放疗前耳蜗及中耳功能良好者 ,放疗后各时期的畸变产物耳声发射幅值虽有变化 ,但与放疗前 1 0kHz[(9 9± 4 9)dB],2 0kHz[(- 0 7± 8 6 )dB],4 0kHz[(2 9± 6 2 )dB],6 0kHz[(1 4± 7 4 )dB]比较 ,经方差分析 ,无明显统计学意义 (P >0 0 5 ) ,DPOAE的结果与骨导听阈的结果一致。【结论】DPOAE可用于鼻咽癌放疗后内耳损伤的检测 ,具有快速、客观、简便、灵敏及无创等优点。

To study the value of distortion product otoacoustic emission(DPOAE) audiogram on examining the radioation injury to the cochlea after radiotherapy for nasopharyngeal carcinoma(NPC). DPOAE and pure audiometry were detected for 40 ears of NPC patients at regular intervals radiotherapy, (before, during, at the end 6 and 12 months after radiotherapy). The different intervals' data were collected and analyzed with statistic methods. Compared with DPOAE audiogram before radiation[1 0 kHz was (9 9±4 9) dB,2 0 kHz was (-0 7±8 6)dB,4 0 kHz was (2 9±6 2) dB,6 0 kHz was (1 4±7 4dB)],DPOAE audiogram of the different intervals were not the same,but there were on significant after difference(P>0 05). The value of DPOAE was similar with the audiometric threshold of bone conduction.[Conclusion] DPOAE can be used in detecting the radiation injuries to the cochlea after radiotherapy. It is simple, objective, sensitive and unwounded.