小剂量红霉素对幼兔心电图QT间期的影响

Influence of low-dosage erythromycin on young rabbits′ electrocardiogram QT-interval

目的 研究小剂量 (30mg/kg)红霉素对幼兔心电图QT间期的急慢性影响。方法 对 1 0个 4～ 5周龄 ,体重 650～ 850g幼兔进行静注 30mg/kg红霉素 ,以皮肤电极获取幼免Ⅱ导心电图 ,以PCLab软件进行心电图分析。结果 用药后 1 0min ,幼兔心电图QT间期即有显著延长 ,并延续至整个用药期间 ,但在用药1 0、2 0、30、40min间幼兔QT间期并无显著差异 ,停药 1 0min ,幼兔QT间期即恢复 ,与用药前无显著差异 ;用药一周的幼兔每天用药期间QT间期均有与急性用药相似的改变 ,但在相同的用药采样点上 ,虽有个别数据间有显著差异 ,但就总体情况而言 ,未得到明显规律。结论 小剂量 30mg/kg红霉素会引起幼兔QT间期延长 ,但慢性影响结果不足以进行红霉素蓄积作用的评估。

Objective To learn the acute and chronic influence of low dosage erythromycin (30mg/kg) on young rabbit′s QT intervals. Methods The young rabbits (4～5years old, 650～850g weight) were given 30mg/kg erythromycin by injection. The ECG were obtained through skin II electrodes. The data of ECG were analyzed by PCLab software. Results 10 minutes after administration, the QT intervals of young rabbits were significantly prolonged, these changes lasted in the whole duration, but there were no significant differences between the QT intervals of the spots of 10, 20, 30 and 40 min respectively. The QT intervals of the young rabbits were recovered 10 min after the use of the drug and having no significant difference with the levels of the initiations. In the course of one week using erythromycin, there were similar changes of QT intervals everyday, but on the same spot, there was no clear conclusion that could be found although some data had singificant difference. Conclusion Low dosage of erythromycin could induce and prolong the QT intervals of young rabbits but the cumulative results of chronic influences of erythromycin could not be estimated at the moment .