人肝细胞性肝癌性激素受体的表达

STUDY ON EXPRESSION OF SEX HORMONE RECEPTOR IN HUMAN HEPATOCELLULAR CARCINOMA

目的 研究人肝细胞性肝癌组织、癌旁组织和正常肝组织中雄激素受体 (AR)和雌激素受体 (ER)的表达水平及分布规律。方法 应用单克隆抗体免疫组化法检测 5 0例肝细胞性肝癌标本的肿瘤组织、癌旁组织和 10例肝内胆管结石的肝组织中 AR和 ER的表达情况。结果 在肝癌组织、癌旁组织和肝内胆管结石的肝组织中 ,AR的阳性表达率分别为 30 %、8%和 0 % ,除癌组织显著高于癌旁组织外 (P<0 .0 1) ,其它各组无显著性差异 (P>0 .0 5 ) ;ER的阳性表达率分别为 12 %、10 %和2 0 % ,在三组中均无显著性差异 (P>0 .0 5 )。在所有阳性片中 ,AR和 ER的标记指数 (L I)均 <2 5。结论 AR和

Objective To study the expression and distribution of androgen receptor(AR) and estrogen receptor(ER) in human hepatocellular carcinoma.Methods Immunohistochemical technique was used to detect the expression of AR and ER in the tumor, surrounding and normal liver tissue. Results In tumor tissue group, surrounding tissue group and control group, the positive rate of AR was 30%, 8% and 0% respectively , while the positive rate of ER was 12%, 10% and 20%. There was no significant difference among all the groups except that the positive rate of AR in tumor tissue group which was significantly higher than that in surrounding tissue group. The labeling index(LI) of AR and ER in all positive specimen were less than 25.Conclusion The expression rate of AR and ER in hepatocellular carcinoma is very low.