联苯/环糊精包合物的药物释放研究

Study on Releasc Drug of Biphenyl in Cyclodextrin (BP/CD) Inclusion Compound

研究了联苯/环糊精(BP/CD)包合物的联苯释放过程。通过比较联苯和BP/CD的热重曲线,发现BP/CD对联苯的稳定作用,对BP/CD及BP/CD填充聚乙烯膜的联苯释放过程进行比较,发现在较薄的填充薄膜中,BP的释放过程是以BP从CD中的解离为控制步骤。此外,还推导了BP/CD的释放反应动力学方程,并计算了活化能。

This paper deals with the releasing process of BP in BP / CD inclusion com-pound.The influence of BP / CD on the stability of BP can be discovered by comparing thedifference of thermogravimetric curve of BP and BP / CD. The releasing process of BP wascontrolled by the dissociation of BP from CD in thinner filled films on comparing the re-leasing process of BP / CD and BP / CD filled in PE films. The releasing reaction kineticsequation of BP / CD was derived and the activation energy was calculated.