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IL-10、IL-12与吉兰-巴雷综合征相关性研究 被引量：1

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摘要 目的　探讨白细胞介素 10 (IL 10 )、白细胞介素 12 (IL 12 )与吉兰 巴雷综合征 (GBS)的关系。方法　用免疫酶联双抗体夹心 (ELISA)法对 3 6例急性期、恢复期GBS患者血清及脑脊液 (CSF)中IL 10、IL 12进行检测。结果　GBS急性期患者血清IL 10水平较对照组未见显著变化 (P >0 0 5 ) ,恢复期则明显升高 (P <0 0 1) ;GBS急性期患者血清IL 12水平较对照组明显升高 (P <0 0 1) ,且其水平与病情分级正相关 ,恢复期明显下降 ;恢复期血清IL 10与IL 12存在负直线相关关系 ;GBS急性期、恢复期CSF中IL 10、IL 12的水平与血清中类似。结论　IL 10、IL 12与GBS的致病过程明显相关 ,IL 10通过下调免疫起保护作用 ,它可能使脱失髓鞘修复 ;IL 12上调免疫参与致病 ,它可能促使脱髓鞘和轴索变性 ;GBS患者血 神经。 1　HartungHP ,PollardJD ,HarveyGK ,etal.ImmunopathogenesisandtreatmentoftheGuillain BarresyndromepartⅠ ,Ⅱ .MuscleNerve ,1995,18:137～ 16 42　ZhuJ ,BaiXF ,MinE ,etal.Cytokinedichotomyinperipheralner voussysteminfluencestheoutcomeofexperimentalallergicneuri tis :dynamicsofmRNAexpressionforIL 1beta ,IL 6 ,IL 10 ,IL 12 ,TNF alpha ,TNF beta ,andcytolysin .ClinImmunolIm munopathol,1997,84 ( 1) :85～ 943　SivieriS ,FerrariniAM ,LoleiF ,etal.Cytokinepatterninthecere brospinalfluidfrom patientswithGBSandCIDP .JNeurolSci,1997,14 7( 1) :93～ 95
作者 刘洪波 连亚军 许予明 方树友
机构地区 郑州大学第一附属医院神经内科
出处 《中国实用内科杂志》 CAS CSCD 北大核心 2002年第11期671-672,共2页 Chinese Journal of Practical Internal Medicine
关键词 吉兰-巴雷综合征 白细胞介素-10 白细胞介素-12
分类号 R745.43 [医药卫生—神经病学与精神病学]
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参考文献2

  • 1Hartung HP,Pollard JD,Harvey GK,et al.Immunopathogenesis and treatment of the Guillain-Barre syndrome part Ⅰ, Ⅱ[].Muscle and Nerve.1995
  • 2Zhu J,Bai XF,Min E,et al.Cytokine dichotomy in peripheral nervous system influences the outcome of experimental allergic neuritis: dynamics of mRNA expression for IL-1 beta, IL-6, IL-10, IL12, TNF-alpha, TNF-beta, and cytolysin[].Clinical Immunology and Immunopathology.1997

同被引文献28

  • 1Buffler M , Becker C , Windisch W, et al. Inflammation neither increases hepatic hepcidin nor affects intestinal (59)Fe-ahsorption in two murine models of bowel inflammation, hemizygous TNF(dAREI+) and homozygous IL-10( -1-) mice[J]. J Trace Elem Med BioI ,2015 ,32: 162-167.
  • 2Garcfa-Rocha R, Moreno-Lafont M, Mora-Garcfa ML, et al. Mesenchymal stromal cells derived from cervical cancer tumors induce TGF -β1 expression and IL-10 expression and secretion in the cervical cancer cells, resulting in protection from cytotoxic T cell activity [J]. Cytokine,2015, 76(2) :382-390.
  • 3Mannino MH, Zhu Z, Xiao H, et al. The paradoxical role ofIL-10 in immunityand cancer[J]. CancerLett, 2015,367 (2) : 103-107.
  • 4Kalampokis I, Yoshizaki A, Tedder TF. IL-10-producing regulatory B cells (BIO cells) in autoimmune disease[J]. Arthritis Res Ther ,2013,15 Suppl 1 :S1.
  • 5Hofmann SR,Riisen-Wolff A,Tsokos GC,et al. Biological properties and regulation of 11-10 related cytokines and their contribution to autoimmune disease and tissue injury[J]. Clin Immunol,2012, 143(2): 116-127.
  • 6Xin J, Wainwright DA,Serpe CJ ,et al. Phenotype of CD4+ T cell subsets that develop following mouse facial nerve axotomy[J]. Brain Behav Immun , 2008,22(4) :528-537.
  • 7Xin J , Wainwright DA , Mesnard NA , et al. IL-I0 within the CNS is necessary for CD4+ T cells to mediate neuroprotection[J]. Brain Behav Immun, 2011 ,25(5) :820-829.
  • 8Villacampa N , Almolda B, Vilella A, et al. Astrocyte-targeted production of IL-10 induces changes in microglial reactivity and reduces motor neuron death after facial nerve axotomy[J]. Glia ,2015,63 (7) : 1166-1184.
  • 9Atkins S, Loescher AR , Boissonade FM , et al. Interleukin-10 reduces scarring and enhances regeneration at a site of sciatic nerve repair[J]. J Peripher Nerv Syst,2007, 12(4) :269-276.
  • 10Koeberle PD, Gauldie J , Ball AK. Effects of adenoviral-mediated gene transfer of interleukin-10, interleukin-4 , and transforming growth factorbeta on the survival ofaxotomized retinal ganglion cells[J]. Neuroscience, 2004,125(4) :903-920.

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中国实用内科杂志
2002年 第11期

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