0、1、6方案接种乙肝疫苗1年后增种10_(μg)免疫效果观察

Observation on Immune Effect of 10_(μg) Enhanced Inoculation One Year after 0,1,6-Month-Scheme Vaccination of Hepatitis B Vaccine

目的 了解军队大学生 0、1、6方案接种重组酵母乙肝疫苗 1年后增种乙肝疫苗的免疫效果。方法 在 0、1、6方案接种重组酵母乙肝疫苗 ( 5 μg 5 μg 5 μg) 1年后 ,随机抽出 2 2 0名一次增种相同厂家同一批号的乙肝疫苗 10 μg ,1月之后用ELISA法检测抗 HBs。结果 711名军队大学生用 0、1、6方案接种重组酵母乙肝疫苗抗 HBs阳转率为 90 .44%( 6 43/711) ,2 2 0名增种者 1月后抗 HBs阳转率为 97.2 7%( 2 14 /2 2 0 ) ,统计学处理P <0 .0 1。所有接种者均未发现严重不良反应。结论 增种重组酵母乙肝疫苗对军队大学生免疫效果有显著提高。

Objective To observe the immune effect of the enhanced injection of hepatitis B one year after 0,1,6-month-scheme vaccination with recombinant yeast hepatitis B vaccine(RYHPV) in millitary college students.Method 711 college students were subcutaneously injected with RYHPV at 0,1,6 month scheme(5μg each time).220 of them were randomly selected and received an enhanced injection of 10μg RYHPV after a year.1 month later,anti-HBs was determined by ELISA in all cases.Results No serious side reactions were found.The positive rate of the anti-HBs in all students was 90.44%(643/711) while in intensive ones it was 97.23%(214/220)(P<0.01).Condusion Enhanced injection of RYHPV could remarkably improve the immune effect in millitary college students.