银心舒粉针剂对大鼠血栓形成的影响

Influence of Yinxinshu Injection on Thrombosis in Rats

目的 探讨银心舒粉针剂对大鼠血栓形成的影响 ,并与金纳多比较其疗效。方法 SD大鼠 40只 ,雌雄各半 ,随机分为银心舒粉针高剂量组、银心舒粉针低剂量组、金钠多组和生理盐水组 ,按相应剂量静脉给药后 ,采用BT 3型体内血栓形成仪电刺激后观察其对颈动脉血栓形成的影响 ;结扎下腔静脉观察其对下腔静脉血栓形成的影响 ,并同时观察了解大鼠纤维蛋白酶活性。结果 银心舒粉针高剂量组、银心舒粉针低剂量组、金钠多组 ,大鼠颈动脉血栓形成时间 ,下腔静脉血栓形成时间均较生理盐水组明显延长 ,前组P <0 .0 1,后两组P <0 .0 5。结论 银心舒粉针明显延长大鼠闭塞性动脉血栓形成时间 ,降低大鼠下腔静脉血栓湿重 ;抑制血栓形成 ,增加纤维蛋白溶解酶活性 ,其作用与剂量成依赖性。

Objective To assess the influence of Yinxinshu injection on the thrombosis in rats,and to compare its efficacy with Ginkgo.Method Forty SD rats(male:20,female:20) were randomly divided into four group which respectively were injected with high dose of Yinxinshu(Group 1),low dose of Yinxinshu(Group 2),Ginkgo(Group 3) and NS(Group 4).After administration,the rats were stimulated with BT-3 Equipment of Thrombosis in Vivo to observe thrombosis of carotid artery.Interior vena cava was ligated and its thrombosis was also observed,fibrinolysin activity of the rats was observed at the same time.Results The times of carotid artery thrombosis and interior vena cava thrombosis in Group 1(P<0.01),2(P<0.05) and 3(P<0.05) were significantly longer than those in Group 4.Conclusions Yinxinshu injection could obviously prolong the time of arterial occlusive thrombosis in rats,reduce the wet weight of interior vena cava thrombus,restrain thrombosis and increase the activity of the fibrinolysin.Its effect depends on its dosage.