慢性疾病性贫血的发病机制

Pathogenic mechanism of anemia of chronic disease

慢性疾病性贫血是一类以血清铁低、总铁结合力低、贮存铁增加为特征的贫血。其发病机制是多因素、多机制的 ,包括细胞因子、一氧化氮、急性时相反应蛋白及促红细胞生成素等所致的红细胞寿命缩短、铁代谢紊乱及骨髓对贫血失代偿等。

Anemia of chronic disease is an anemia characterized by reduced serum iron concentrations, total iron binding capacity, whereas iron stores are increased. The pathogenesis is multifactors and multimechanisms:cytokines,natric oxide, acute phase proteins and erythropoietin contribute to shortened red survival, iron metabolism disorders and blunted bone marrow response to anemia.