食管癌中细胞粘附分子E-钙粘素和CD44变异体表达及其临床意义

Expression and significance of E-CD and CD44V6 in esophageal squamous cell carcinoma

目的 探讨细胞粘附分子E 钙粘素 (E CD)和CD44变异体 (CD44V6)的表达与食管癌临床病理及预后的关系。方法 对 5 8例食管癌标本应用SP免疫组化染色法进行E CD、CD44V 6检测 ,并对其中 42例进行术后 3年随访。结果 E CD低表达和CD44V 6高表达与食管癌的浸润转移、复发和预后相关 (P <0 .0 5 )。E CD低阳性表达率与食管癌细胞分化程度相关 (P <0 .0 5 )。食管癌中E CD和CD44V6的表达无相关性 (P >0 .0 5 )。结论 E CD和CD44V 6在食管癌中的表达与食管癌的发生发展、侵袭转移和预后密切相关 ,E CD和CD44V6在食管癌中的表达无相关性 ,在食管癌的发生、发展、侵袭转移中是 2个独立的调节因子 。

objective To investigate the expression of E CD and CD44V6 and their clinical significance in patients with esophageal squamous cell carcinoma.Methods E CD and CD44V6 expressions were determined in paraffin embedded tissues from 58 cases with esophageal squamous cell carcinoma by immunohistochemical methods. Forty two cases were followed up for 3 years.Results Low expression of E CD and over expression of CD44V6 were closely related with the invasion,metastasis,recurrence and prognosis of esophageal squamous cell carcinoma ( P <0.05).The correlation was observed between low E CD expression and cellular differentiation ( P <0.05).No significant correlation was found between E CD expression and CD44V6 expression in these patients ( P >0.05).Conclusions The expressions of E CD and CD44V6 correlate with the development,invasion,metastasis and prognosis of esophageal squamous cell carcinoma.No correlation of E CD and CD44V6 expression is demonstrated in esophageal squamous cell carcinoma,suggesting that as independent function regulating factors in esophageal squamous cell carcinoma E CD and CD44V6 can be regarded as important signs of invasion?metastasis and prognosis.