川芎素对肾性高血压并慢性肾功能不全患者血浆ET-1和NO的影响

Effects of sodium ferulate on plasma levels of endothelin-1 and nitric oxide in patients with renal hypertension and chronic renal insufficiency

目的 :观察轻、中度肾性高血压合并慢性肾功能不全患者血浆ET 1和NO水平变化及川芎素对其干预作用。方法 :轻、中度肾性高血压并慢性肾功能不全患者 6 0例分为A与B组 ,A组静滴川芎素 30 0mg ,每日 1次 ,加对症治疗 ;B组采用对症治疗 ,疗程均为 2周。选择 2 0例健康体检者作为对照组 (C组 )。用放射免疫方法测定血浆ET 1浓度和生化比浊法测定血浆NO水平。结果 :A ,B组血浆ET 1浓度明显高于C组 (P <0 .0 1) ,而血浆NO浓度明显低于C组 (P <0 .0 1)。A与B两组治疗前、后血浆ET 1,NO ,BUN ,Scr,尿蛋白定量比较差异有显著性 (P <0 .0 1)。ET 1与血压成正相关 (γ =0 .5 2 9P <0 .0 1) ,而NO与血压成负相关 (γ =- 0 .345 ,P <0 .0 1)。结论 :轻、中度肾性高血压并慢性肾功能不全患者血浆ET 1浓度高于正常人 ,血浆NO浓度低于正常人。川芎素具有调节患者血浆ET 1与NO浓度 ,减少尿蛋白排泄 。

Objective To observe the changes of plasma Endothelin 1 (ET 1) and nitric oxide (NO), and the treatment effect of sodium ferulate on patients with renal hypertension and chronic renal insufficiency. Methods Group I: sixty patients with renal hypertension and chronic renal insufficiency were divided into two groups randomly: A and B. The patients in Group A were treated with sodium ferulate and the routine therapy while those in Group B were treated only with the routine therapy. The serum concentration of ET 1 and NO were measured. Results The level of plasma ET 1 was higher and the level of NO was lower in Group A and B than those in Group C (P<0.01). In Group A, plasma ET 1, BUN, Scr and urinary protein decreased while plasma NO increased significantly after the treatment (P<0.01). Compared with Group B those changes in Group A were more significant (P<0.01). There was a positive correlation between ET 1 and Bp. There was a negative correlation between NO and Bp. Conclusion The level of plasma ET 1 of the patients was markedly higher than that of the normal subjects in the control group, while NO was markedly lower. Sodium ferulate can regulate the balance of plasma ET 1 and NO in patients with renal hypertension and chronic renal insufficiency. Sodium ferulate plays an important role in protecting renal functions and delaying chronic renal failure.