慢性老年精神分裂症患者认知功能及其与日常生活能力的比较研究

Comparative study of the cognitive function and activity of daily living in geriatric schizophrenic patients

目的 :了解慢性老年精神分裂症患者认知功能和日常生活能力状况 ,探讨此类患者在额叶执行功能和记忆方面的神经心理功能障碍及其特征。方法 :采用简易智力状态检查 (MMSE)、日常生活能力量表 (ADL)、威斯康星卡片分类测验 (WCST)及韦氏记忆量表 (WMS)对 31例慢性老年精神分裂症和 31例正常对照组进行比较研究。结果 :慢性老年精神分裂症组MMSE得分明显低于正常对照组 (P <0 .0 1) ;而该组ADL总分明显高于正常对照组(P <0 .0 5 )。除非持续错误外 ,慢性老年精神分裂症患者的威斯康星卡片分类测验和韦氏记忆量表的各项测验成绩均差于对照组 (P <0 .0 5 )。结论 :慢性老年精神分裂症患者认知功能的障碍决定了患者日常生活能力的减退 ;

Objective To understand the cognitive function and activity of daily living in geriatric schizophrenic patients and to explore neuropsychologic dysfunction in the frontal executive function and memory of these patients. Methods Thirty one geriatric schizophrenic patients and 31 normal subjects were studied with the Mini Mental State Examination (MMSE), Activity of Daily Living Scale (ADL), Wisconsin Card Sorting Test (WCST), and Wechsler Memory Scale (WMS). Results There was a significant difference between the normal subjects and geriatric schizophrenic patients in MMSE (P<0.01). The ADL scores were significantly higher and the scores of WMS and WCST were significantly lower in the patients with geriatric schizophrenia than in the normal subjects (All P<0.05). Conclusion The disorder of the cognitive function is related to the handicap of activity of daily living, and dysfunction of the frontal executive function and memory exists in geriatric schizophrenic patients.