鲤亚急性喹乙醇中毒组织中药物浓度的研究

Tissue concentration of subacute olaquindox poisoning in common Cyprinus carpio

在饲料中分别添加1、2、3g/kg的喹乙醇,对鲤Cyprinuscarpio进行了亚急性毒性试验,并对中毒的鲤进行了血液生化指标的测定。经过6周的试验,各组的发病率分别为35%、70%、92 5%;死亡率为27 5%、57 5%、82 5%。中毒的鲤表现为特征性的"应激性出血综合症",用高效液相色谱法测定中毒鲤组织中的喹乙醇浓度,结果表明,肝组织中的浓度最高,肾中次之,肌肉中含量最低,且肝、肾组织内的喹乙醇含量与对照组间有显著(p<0 05)或极显著(p<0 01)的差异。

The tissue concentration of subacute olaquindox poisioning was determined in common Cyprinus carpio fed the feed supplemented with 1,2 or 3 g/kg feed using high performance liquid chromatography (HPLC) for 6 weeks. The morbidity and mortality of the animals were 35%,70%,92.5% and 27.5%,57.5%,82.5%, respectively. The clinic symptom of the poisoned fish was characterized by 'the stress hemorrhage syndrome'. The results indicated that the concentration of olaquindox was the highest in livers, followed by in kidneys, and the lowest in muscles. The concentration of olaquindox in muscles, livers and kidneies of the treated groups were significantly different from the control group.