基因治疗在周围神经损伤修复中的应用

Application of gene therapy in the repair of peripheral nerve injury

随着分子生物学研究的飞速发展 ,基因治疗在基础和临床得到了广泛的应用 ,在周围神经损伤修复领域表现出尤为广阔的前景。目前 ,基因治疗修复周围神经损伤的基本策略是利用载体工具将编码神经营养因子的基因转入靶细胞 ,使之在体内持续表达 ,进而达到治疗效果。本文着重就神经营养因子、靶细胞、载体工具 3个方面介绍当前国际上基因治疗修复周围神经损伤的研究情况。

Following rapid progress of research on molecular biology,gene therapy has been widely applied to experimental study and clinical application. It shows great potential in repairing peripheral nerve injury. And now the basic strategy of gene therapy in repairing peripheral nerve injury is to make the gene,which encodes neurotrophic factor express constantly in target cell in vivo by vectors. This review will introduce the latest progress of this new technique including neurotrophic factors,target cells and vectors.