Azone与DPPC脂质体相互作用的^1HNMR研究

~1HNMR STUDIES ON THE INTERACTON OF AZONE WITH DPPC LIPOSOME

用~1HNMR方法研究了透皮吸收促进剂Azone与DPPC脂质体的相互作用.结果表明,Azone限制DPPC头部某些基团的运动.机理可能是Azone的十二烷基插入膜中,其ε-已内酰胺环靠近脂质头部.

The interaction of 1-dodecylazacycloheptan-2-one(Azone) known as a skin permeation enhancer with DPPC liposome is studied by ~1HNMR technique.The results indicate that the motion of some head groups in DPPC is restricted by Azone.The possible molecular mechanism is that the dodecyl group of Azone penetrates into the membrane and its ε-capro- lactam ring is near the polar head of DPPC.