摘要
目的探讨PELP1和Ki67在子宫内膜癌中的表达及与临床病理特征之间的关系,分析PELP1与Ki67之间的相关性及其与子宫内膜癌预后之间的关系。方法采用免疫组织化学Envision二步法,检测76例子宫内膜癌标本中PELP1和Ki67蛋白的表达情况。结果PELP1和Ki67蛋白均定位于子宫内膜癌组织的细胞核中。子宫内膜癌细胞中,PELP1的表达随分化程度的降低而增强(P<0.05),随肌层浸润的深度增加而增强(P<0.01),随手术-病理分期的进展而增强(P<0.01)。Ki67的表达随分化程度的降低而增强(P<0.01),随手术-病理分期的进展而增强(P<0.05)。PELP1与Ki67表达具有相关性(P<0.05,r=0.244)。结论在子宫内膜癌中PELP1、Ki67均为高表达,二者呈正相关,在子宫内膜癌的发生、发展中可能起促进作用。
Objective This study was designed to explore the expression of PELP1 and Ki67 proteins in endometrial cancer and the relation with clinical pathology factor, analyze the correlation between PELP1 and Ki67,the relationship between the expression of PELP1 or Ki67 and the prognosis of endometrial carcinoma. Methods Immunohistochemistry( Envision) was applied for the dectection of PELP1 and Ki67 protein expressions in 76 endometrial cancer patients. Results The PELP1 and Ki67 protein were located in the nucleus of tumor cells. The expression of PELP1 protein was enhanced with the decrease of differentiation( P < 0. 05),the increase of the depth of myometrial invasion( P < 0. 01)and the progress of surgical-pathologic staging( P < 0. 01). The expression of Ki67 protein was enhanced with the decrease of differentiation( P < 0. 01) and the progress of surgical-pathologic staging( P < 0. 05).The expression of PELP1 protein was correlated with the expression of Ki67 in endometrial cancer( P < 0. 05,r = 0. 244). Conclusions PELP1 and Ki67 are highly expressed in endometrial cancer.The expresssion of PELP1 is positively correlated with the level of Ki67 in endometrial cancer, which suggests they may have a promoting effect in the occurrence and development of endometrial cancer.
出处
《妇产与遗传（电子版）》
2016年第4期41-45,共5页
Obstetrics-Gynecology and Genetics (Electronic Edition)
基金
广东省科技计划项目(2011B031800367)
