摘要
目的:探讨血清瘦素水平与脂肪含量,年龄,性别,血糖,胰岛素的关系。方法:85例受试者按体质量指数(BMI)分为3组:Ⅰ线BMI<23kg/m^2 20例,Ⅱ组kg/m^2≤BMI<25kg/m^2 18例,Ⅲ组BMI≥25kg/m^2 47例,测定其空腹血清瘦素水平,空腹血糖,空腹胰岛素、身高、体质量,收缩压,舒张压,脂肪百分数,甘油三酯、总胆固醇等。结果(1)女性瘦素浓度高于男性(P<0.01),Ⅲ组瘦素水平高于Ⅱ组和Ⅰ组;(2)血清瘦素水平与BMI(r=0.471,P<0.01),脂肪百分数(r=0.318,P<0.01),胰岛素(r=0.388,P<0.01)、甘油三酯(r=0.371,P<0.01)、胆固醇(r=0.491,P<0.01)和收收缩压(r=0.220,P<0.05)成正相关。结论:性别、脂肪含量、空腹胰岛素、血脂与瘦素存在着显著的相关性,高瘦素血症和瘦素抵抗可能与高胰岛素血症、胰岛素抵抗和2型糖尿病有关。
Objective\ To explore the relationship between serum leptin levels and body fat,plasma glucose ,serum lipid and insulin concentrations. Methods\ 85 individuals were divided into three groups according to body mass index(BMI): groupⅠ BMI<23 kg/m 2(n=20),groupⅡ23 kg/m 2≤BMI<25 kg/m 2 (n=18),group Ⅲ BMI≥25 kg/m 2(n=47),and fasting serum leptin,plasma glucose,plasma insulin,height,weight,percent of fat,systolic pressure,diastolic pressure,triglyceride,serum total cholesterol etc.were measured.Results\ (1)serum leptin levels in females were significantly higher than that in males (P<0.01),and serum leptin concentrations of group Ⅲ were significantly higer than those of groupⅡand groupⅠ.(2) Fasting plasma leptin levels were positively correlated with BMI (r=0.471, P<0.01),percent of fat (r=0.318,P<0.01),insulin (r=0.388, P<0.01),serum total cholesterol (r=0.371,P<0.01), triglyceride ( r=0.491,P<0.01),and systolic pressure (r=0.220, P<0.05). Conclusion\ Hyperleptinemia and leptin resistance might be involved in the development of hyperinsulin,insulin resistance and type 2 diabete.
出处
《医师进修杂志》
北大核心
2002年第11期15-17,共3页
Journal of Postgraduates of Medicine
关键词
血清
瘦素
肥胖
胰岛素
血脂
leptin
obesity
insulin
serum lipid
diabetes mellitus