人血清瘦素水平与肥胖、胰岛素和血脂的关系

RELATIONSHIP OF HUMAN SERUM LEPTIN WITH INSULIN SERUM LIPIDS AND OBESITY

目的：探讨血清瘦素水平与脂肪含量，年龄，性别，血糖，胰岛素的关系。方法：85例受试者按体质量指数（BMI）分为3组：Ⅰ线BMI＜23kg/m^2 20例，Ⅱ组kg/m^2≤BMI<25kg/m^2 18例，Ⅲ组BMI≥25kg/m^2 47例，测定其空腹血清瘦素水平，空腹血糖，空腹胰岛素、身高、体质量，收缩压，舒张压，脂肪百分数，甘油三酯、总胆固醇等。结果（1）女性瘦素浓度高于男性（P＜0．01），Ⅲ组瘦素水平高于Ⅱ组和Ⅰ组；（2）血清瘦素水平与BMI（r=0.471,P<0.01)，脂肪百分数（r=0.318,P<0.01)，胰岛素（r=0.388,P<0.01)、甘油三酯（r=0.371,P<0.01)、胆固醇(r=0.491,P<0.01)和收收缩压（r=0.220,P<0.05)成正相关。结论：性别、脂肪含量、空腹胰岛素、血脂与瘦素存在着显著的相关性，高瘦素血症和瘦素抵抗可能与高胰岛素血症、胰岛素抵抗和2型糖尿病有关。

Objective\ To explore the relationship between serum leptin levels and body fat,plasma glucose ,serum lipid and insulin concentrations. Methods\ 85 individuals were divided into three groups according to body mass index(BMI): groupⅠ BMI<23 kg/m 2(n=20),groupⅡ23 kg/m 2≤BMI<25 kg/m 2 (n=18),group Ⅲ BMI≥25 kg/m 2(n=47),and fasting serum leptin,plasma glucose,plasma insulin,height,weight,percent of fat,systolic pressure,diastolic pressure,triglyceride,serum total cholesterol etc.were measured.Results\ (1)serum leptin levels in females were significantly higher than that in males (P<0.01),and serum leptin concentrations of group Ⅲ were significantly higer than those of groupⅡand groupⅠ.(2) Fasting plasma leptin levels were positively correlated with BMI (r=0.471, P<0.01),percent of fat (r=0.318,P<0.01),insulin (r=0.388, P<0.01),serum total cholesterol (r=0.371,P<0.01), triglyceride ( r=0.491,P<0.01),and systolic pressure (r=0.220, P<0.05). Conclusion\ Hyperleptinemia and leptin resistance might be involved in the development of hyperinsulin,insulin resistance and type 2 diabete.