恶性血液病患者肠道双歧杆菌的定量调查

Quantitative investigation of intestinal bifidobacterium of patients with malignant hematological disease

目的 研究恶性血液病患者化疗前后肠道双歧杆菌 (Bifidobacterium)数及检出率的变化情况。方法 用自制改良BS培养基对 5 2例恶性血液病患者化疗前后大便进行双歧杆菌定量检测。结果 恶性血液病患者肠道双歧杆菌数较正常人明显减少 ,化疗前肠道双歧杆菌检出率为 44 2 % ,化疗后肠道双歧杆菌检出率为 15 4% ,较化疗前检出率显著降低 (P <0 0 1)。结论 恶性血液病患者化疗前后肠道双歧杆菌数有明显的变化 ,调节恶性血液病患者肠道微生态平衡 ,有助于促进恶性血液病患者健康状况的改善。

Objective To study the changes of intestinal bifidobacterium count before and after chemotherapy in patients with malignant hematological diseases Methods Intestinal bifidobacterium count before and after chemotherapy in 52 cases of malignant hematological diseases was investigated by improved BS medium Results Intestinal bifidobacterium count of patients with malignant hematological diseases was lower than that of normal persons The detected rates of bifidobacterium in patients with malignant hematological disease were 44 2% (in 10 -6 dilution degree)before chemotherapy and 15 4% (in 10 -6 dilution degree)after chemotherapy Intestinal bifidobacterium count of patients with malignant hematological diseases after chemotherapy was lower than before chemotherapy( P <0 01) Conclusion There are some changes of intestinal bifidobacterium count in patients with malignant hematological diseases before and after chemotherapy The regulation of the intestinal microecological balance of patients with malignant hematological diseases after chemotherapy is beneficial to the amelioration of health of patients