结直肠癌中抑癌基因ING1蛋白的表达及其意义

Expression and significance of tumor suppressor ING1 in colorectal cancers

目的 了解大肠癌中ING1表达及其意义。方法 采用免疫组织化学方法检测 5 2例大肠癌组织及正常大肠粘膜中ING1及p5 3蛋白表达。结果 在 5 2例大肠癌组织中ING1蛋白表达较正常粘膜明显减弱 (+ + :9 6% ;+ :3 8 5 % ) ,其表达减弱与Dukes分期及淋巴结转移情况有关 ,ING1蛋白表达与p5 3蛋白表达有关。结论 ING1蛋白表达下调在大肠癌发生、发展过程中起重要作用 ,表达情况与大肠癌的Dukes分期及转移。

Objective To explore the correlation between the expression of ING1 and the clinicopathological features in patients with colorectal cancer, and investigate the possible mechanism of ING1 in the oncogenesis of colorectal cancer. Methods All samples of normal mucosa and cancer tissues from 52 patients with colorectal cancer were detected for their protein expression levels of ING1 with the SP immunohistochemical staining. Results Diminished expression of ING1 protein was found in colotrectal tissue (++:9.6%;+:38.5%). The suppression of P33/ING1 expression was markedly related to the Dukes Stage and metastasis. A parallel relationship was found between the expression of ING1 and p53. Conclusion Down regulation of ING1 may play an important role in the oncogenesis and development of colorectal carcinoma. Its content has a relation to Dukes stage and tumor metastasis, and might serve as a prognostic factor of colorectal carcinoma.