摘要
b Department of Chemistry, Wuhan University, Wuhan, Hubei 430072, China The action of β ( N selenomorpholine) ethyl phenyl ketone hydrochloride and 4 ( N selenomorpholine) 2 butanone hydro chloride on Escherichia coli and Staphylococcus aureus was studied by microcalorimetry. Differences in their capacities to affect the metabolism of this bacterium were observed. The kinetics shows that the selenomorpholine compounds had action on the metabolism process of Escherichia coli and Staphylococcus aureus. The rate constant ( k ) of the studied bacterium in the presence of the drugs are concentration dependant. The growth rate constants decrease with an increase in the mass of the selenomorpholine compounds, but their relationship is different. As deduced from the rate constant ( k ) of the studied bacterium (in log phase) and the half inhibitory concentration (IC 50 ), the experimental results reveal that the studied selenomorpholine compounds all have good antibiotic activity and better antibacterial activity on Staphylococcus aureus than on Escherichia coli.
b Department of Chemistry, Wuhan University, Wuhan, Hubei 430072, China The action of β ( N selenomorpholine) ethyl phenyl ketone hydrochloride and 4 ( N selenomorpholine) 2 butanone hydro chloride on Escherichia coli and Staphylococcus aureus was studied by microcalorimetry. Differences in their capacities to affect the metabolism of this bacterium were observed. The kinetics shows that the selenomorpholine compounds had action on the metabolism process of Escherichia coli and Staphylococcus aureus. The rate constant ( k ) of the studied bacterium in the presence of the drugs are concentration dependant. The growth rate constants decrease with an increase in the mass of the selenomorpholine compounds, but their relationship is different. As deduced from the rate constant ( k ) of the studied bacterium (in log phase) and the half inhibitory concentration (IC 50 ), the experimental results reveal that the studied selenomorpholine compounds all have good antibiotic activity and better antibacterial activity on Staphylococcus aureus than on Escherichia coli.
基金
theNationalNaturalScienceFoundationofChina (Nos .2 99730 30and 30 170 0 10 )
ChenguangProjectFoundationofWuhan (No .2 0 0 2 5 0 0 10 0 9)
