甲状腺癌病人接受大剂量^(131)I治疗后常见副作用的调查研究

Study of immediate and long-term side effects on thyroid cancer patients caused by high-dose radioiodine therapy

分化良好的甲状腺癌病人预后较好 ,但大剂量放射性13 1I治疗后会给病人带来多方面的副作用。本文研究了甲状腺癌病人接受大剂量13 1I治疗后 ,常见副作用的发生及其与累积治疗剂量间的关系。根据13 1I治疗后常见的副作用 ,选择了 10个问题建立标准问卷 ,由高年资的核医学医师对病人进行随访 ,对问卷回答结果进行分析比较。结果表明 ,涎腺炎的晚期症状和严重的口干症状与13 1I治疗剂量大小密切相关。研究提示 ,在治疗过程中要采取一些必要的方法 ,尽可能减少副作用的发生 ,以提高病人的生活质量。

The well differentiated thyroid cancer patients had a better prognosis. High-dose radioiodine therapy may induce immediate and long-term side effects to patients. The aim of this paper is to investigate the side effects after high-dose radioiodine therapy on thyroid cancer patients and the relation with cumulative therapy dosage. According to the common side effects of 131I therapy, 10 questions was chosen to set up a standard questionnaire. Patients were followed up by senior nuclear medicine physicians and the results were analyzed and compared. The results showed that the late symptom of sialadenitis and severe dry mouth were intensively related with cumulative therapy dosage. It is suggested that during the therapy certain necessary means should be adopted to reduce the potential side effects and improve the patients' life quality.