bFGF治疗儿科常见口腔粘膜炎症的临床疗效评价

The clinical evaluation on bFGF for the treatment of pediatric stomatitis

目的 观察碱性成纤维细胞生长因子 (bFGF)对儿科几种常见口腔粘膜炎症的治疗作用。方法 各种口腔粘膜炎症患者 4 32例 ,按不同病种各随机分为两组。bFGF组在常规处理的基础上采用bFGF生理盐水溶液口腔病变局部喷涂 ;对照组在常规治疗的基础上局部喷涂生理盐水。用药前后半小时内禁止饮食。观察疼痛、充血程度或口腔溃疡面积 (直径 )以及愈合时间的变化。结果 bFGF组疼痛程度明显减轻 ,疼痛时程显著缩短 ,病变愈合时间显著提前 ;总有效率bFGF组达 99.1% ,对照组为 5 4 .4 %。近期观察未见不良反应 ,长期随访亦未见明显毒副作用。

Objective To investigate the clinical effect of bFGF on stomatitis caused by the common reasons in pediatrics. Methods 432 patients with stomatitis were randomly divided into 2 groups.bFGF saline solution was administered locally to the bFGF group,and the control group was given normal saline.The pain,congestion and diameter of lesion were examined after treatment.Results In bFGF group, pain was lessened and the healing time was shortened significantly.The total effective rate was 99.1 % in bFGF group and 54.4 % in control group.No side effect was noted during short-term follow-up.Conclusion bFGF can cure oral mucitis effectively.