日粮添加丁酸钠对低初生重新生仔猪生长性能及肠道发育的影响

Effects of dietary sodium butyrate on the growth performance and intestinal development in newborn piglets with low birthweight

研究旨在考察代乳日粮中丁酸钠对低初生重仔猪生长性能、肠道形态、消化酶活性、肠道养分转运载体表达量的影响。选用16头正常初生重(NBW)和16头低初生重(LBW)DLY仔猪,从7日龄开始分别饲喂基础日粮或添加3 kg/t丁酸钠的代乳日粮,试验期14 d。结果表明,LBW仔猪的日增重显著低于NBW仔猪(P<0.05),日粮添加丁酸钠显著提高LBW及NBW仔猪的日增重(P<0.05)。日粮添加丁酸钠显著提高LBW仔猪的料重比(P<0.05),但对NBW仔猪料重比影响差异不显著(P>0.05)。日粮添加丁酸钠显著改善了LBW仔猪的绒毛高度、绒毛高度与隐窝深度比值、乳糖酶活性、肠道养分转运载体SGLT1和GLUT2基因表达量(P<0.05)。代乳日粮中添加丁酸钠可改善新生LBW仔猪肠道发育并改善新生期的生长性能。

The objective of the present study was to examine the effects of dietary sodium butyrateon the growth performance, intestinal morphology, digestive enzyme activities and nutrient transport-er expressions in piglets born with low birthweight. Sixteen normal birthweight(NBW) and sixteenlow birthweight(LBW) DLY piglets were fed a basal diet or basal diet supplemented with 3 kg/t so-dium butyrate from 7 d postnatal and test lasted for 14 days. The average daily gain(ADG) inLBW piglets was significantly lower than NBW piglets(P<0.05), and ADG was significantly improvedby dietary sodium butyrate supplementation in both LBW and NBW piglets(P<0.05). Feed??gain ra-tio was greater in LBW piglets fed diets without sodium butyrate compared with LBW piglets withsodium butyrate supplementation(P<0.05), but was similar in NBW piglets with or without sodiumbutyrate supplementation. Dietary sodium butyrate supplementation significantly improved the villousheight, ratio of villous height to crypt depth, lactase activity and m RNA expressions of intestinaltransporters(SGLT1 and GLUT2) in LBW pig-lets. Collectively, these results demonstratedthat dietary sodium butyrate supplementation inmilk replacer could improve the intestinal devel-opment and growth performance of piglets bornwith LBW.