摘要
对阿尔采默氏病(Alzheimer Disease,AD)的可能危险因素进行了病例对照研究。126例临床确诊为 AD的病例,实施1:2匹配,以年龄、性别、民族、居住区为匹配条件的252名非痴呆者作为对照。发现与AD发生有明显关联的因素有:一级亲属痴呆家族史,一级亲属重性精神病家族史;病前兴趣狭窄以及一生中经历的重大生活事件。未发现Down氏症家族史及脑外伤史或过敏性疾病等与AD发生有明显关联。
A case control study to assess the possible risk factors associated with Alzheimer's discase (AD)among Chinese population was conducted on 126 clinically diagnosed AD patients and 252 matchedby sex, age, nationality region as control. Factors significantly associated with AD caseswere, family history of dementia in first degree relatives, family history of psychoses in first degreerelatives, few interesls and heavy negative life events during individuat's life time Neither famity his-tory of Down's syndrome, antecedent history of head trauma, nor other condition that might supportimmune hypotheses were significantly associated with AD cases The data from this study support thefamily genetic hypothese of AD and also the role of psychosocl factors in AD.
出处
《北京医科大学学报》
CSCD
1992年第4期334-337,共4页
Journal of Peking University(Health Sciences)
基金
卫生部科研基金
关键词
阿尔采默氏病
危险因素
痴呆
Alzheimer's disease
Risk factors
Case control study
