膀胱癌生物学特性的研究

BIOLOGIC BEHAVIOR OF BIADDER CANCER

本文总结了近年来我所有关膀胱癌生物学特性的临床及实验研究。临床方面研究了膀胱癌伴随的粘膜病变对肿瘤发生发展的影响,并对BCG治疗膀胱癌的近远期疗效作了观察。实验研究主要是建立了膀胱癌细胞系(BIU-87),制备了膀胱癌单克隆抗体,应用单抗对载瘤裸鼠进行了放射免疫肿瘤显像,在体内外显示了偶联上阿霉素的单抗对膀胱癌细胞的特异杀伤作用,对膀胱癌基因的表达进行了研究。

Clinical and experimental researches on biologic behayior of bladder cancer in our Institute in recentyears have been summarized. Clinical studies revealed the influence of mucosal lesions accompaniedwith bladder cancer on the occurrence and progress of the tumor, short and long term herapeutic effectof intravesical BCG instillation for bladder cancer. Experimental reseaches included the establishmentof epithelial cell line BIU-87 from a human bladder transitional cell carcinoma, the production of amonoclonal antibody (BDI-1) against human bladder carcinoma. radioimmunoimaging of the human blad-der cancer xenografts by ^(3)I labeled monoclonal antibody BDI 1, specific killing effect of monoclonalantibody BDI-1 conjugated adriamycin on bladder tumor, and the expression of oncogenes of human blad-der cancer (Southern blot and Northern blot).