咪唑安定(Midazolam)和舒乐安定(Estazolam)对睡眠障碍疗效的对照观察

A comparative study of Midazolam and Estazolam treatment on sleep disturbances.

对21例睡眠障碍患者采用单盲自身对照比较观察,发现咪唑安定对缩短入睡时间和减少做梦较舒乐安定为佳,但对夜间醒觉次数、醒后情况、副作用和对睡眠的评价4项,因例数较少,还不能得出肯定的结论,需进一步研究观察。

Twenty-one outpatients with sleep disturbances who had completed therapy with hypnotics were observed under single-blind self-comparable method each for 5 days. We found that patients treated with Midazolam did significantly better than patients with Estazolam in respect to the time of onset of sleep and reduction of dreaming. However, the other 4 items, such as nocturna. awakening, feeling after awakening from sleep, side effects of drugs and quality of sleep could not be evaluated well, because the number of patients was too small. It needs further investigation.