复合透皮促渗剂对氨氯地平的促渗透作用

Effect of Compound Penetration Enhancers on Permeability of Amlodipine Through Rabbit Skin

目的 :研究不同透皮促渗剂对氨氯地平混悬液的体外兔皮渗透作用。方法 :以 3 0 %乙醇为溶媒 ,分别配制含不同透皮促渗剂的氨氯地平饱和混悬液 ,采用自制改良Franz’s扩散池测量其对体外兔皮的促渗透作用。结果 :促渗剂对氨氯地平均有促渗透作用 ,不同透皮促渗剂促透作用的大小顺序为 :丙二醇 <油酸 <阿佐恩 <阿佐恩 +丙二醇 <油酸 +丙二醇。与不含促渗剂相比 ,油酸 +丙二醇渗透系统稳态透皮渗透速率约为不含促渗剂的 2 .7倍。结论 :复合透皮促渗剂对氨氯地平有良好的促渗透作用。

Objective:To study the effect of compound penetration enhancers on the in vitro permeability of amlodipine from the suspension through rabbit skin. Method:30% ethyl alcohol is used as solvent and mixed with amlodapine saturated suspension containing different kinds of penetration enhancers. Then its permeability effect through rabbit skin was determined by using the Franz's type diffusion cell. Results:The penetration rates of amlodipine increased by enhancers in the following order : propylene glycol<oleic acid<Azone<Azone +propylene glycol<oleic acid+propylene glycol. The steady speed of oleic acid and propylene glycol was probably 2.7 times as that without adding enhancers. Conclusion:Compound penetration enhancers had good effect on the in vitro permeability of amlodipine from the suspension through rabbit skin.