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依哌唑胺中间体的合成

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摘要 合成依哌唑胺中间体N-苄氧羰基-3-氟-4-(N-苄氧羰基哌嗪基)苯胺Ⅰ以及(S)-N-[2-(乙酰氧基)-3-氯丙基]乙酰胺Ⅱ。以3,4-二氟硝基苯原料,经过取代、还原、硝化3步反应制备中间体Ⅰ。以S-环氧氯丙烷为原料经过2步反应制备中间体Ⅱ。通过实验进行条件优化,最终总收率分别为54.8%和59.3%。该化合物同时也是合成噁唑烷酮类化合物的重要的中间体。
出处 《化工管理》 2014年第18期189-189,共1页 Chemical Engineering Management
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