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硝唑尼特的合成研究

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摘要 本文对硝唑尼特的合成路线以及反应条件进行了研究,确定了合成硝唑尼特的路线为乙酰水杨酸为起始原料,经草酰氯酰氯化后再与2-氨基-5硝基噻唑反应生成目标产物。该合成路线下的最优反应条件为:酰氯化与酰胺化均使用二氯甲烷作为反应溶剂;物料比例为n(草酰氯):n(乙酰水杨酸)=2,n(乙酰水杨酰氯):n(2-氨基-5-硝基噻唑)=1.4;酰胺化步骤以三乙胺为缚酸剂。
出处 《化工管理》 2016年第21期106-,共1页 Chemical Engineering Management
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