考虑淋巴微循环的体循环分析

Analysis of human blood circulation with lymph microcirculation

基于流体网络动力学和电路图论原理建立了带有淋巴系统的人体血液循环流体网络模型,用10次谐波来模拟流量表达式。改变模型分支流阻,从血流动力学层面来模拟淋巴分支对血液循环的影响以及各分支之间的相互影响。用平均法求解模型中的血流动力学宏观参数,并从生物物理角度讨论了淋巴分支对微循环的影响。结果表明:淋巴循环障碍,淋巴分支流阻比η=3时,该分支平均流量相对于正常值减小42.24%,对其他分支流量影响不超过0.04%;各分支的流阻变化会对淋巴分支的流量产生至少2.69%的影响。

We built a fluid network model of human blood circulation with lymphatic system based on fluid network dynamics and circuit graph theory,and used first 10 harmonios waves to simulate the blood flow equation.In hemodynamics respect,the effect of lymph branch on systemic circulation and mutual influences of every branch were simulated by changing the branches resistance in the model.Hemodynamics parameters were obtained by average method of adaptive control,and the biophysical effect of the lymphatic system on microcirculation was discussed.The results show that,when lymphatic microcirculation has a disorder,and lymph branch flow resistance ratio isη=3,the average flow of this branch is decreased by 42.24%,and the relative decrease in the awerage flow of other branches in not more than 0.04%.The changes in the flow resistance of other branches will lead to a decrease by at least 2.69%of the lymphatic branch flow.This study provides reference for analysis of microcirculation disorder and the relation between systemic circulation and microcirculation.