摘要
目的 :研究FasL、P2 7、PCNA在胃癌组织中的表达 ,并探讨其生物学意义。方法 :采用免疫组化SP法检测 5 0例胃癌组织、癌旁交界组织、距肿瘤边缘 5cm组织及 10例正常胃粘膜的FasL表达 ,并对正常胃粘膜和肿瘤组织中P2 7、PCNA表达进行检测。结果 :胃癌TNM分期、分化程度、淋巴结转移与FasL表达无关 (P >0 0 5 ) ,与P2 7、PCNA表达有关 (P <0 0 1)。结论 :FasL可能在胃癌发生发展过程的免疫逃避中起重要作用 ;P2 7蛋白可能是一个预测胃癌预后的重要因素 ;PC
Objective:To study the expression of FasL, P27, PCNA in gastric cancer.Methods:50 gastric cancer specimens and 10 cases of normal gastric mucosa were collected and continuous paraffin slices were made from the normal gastric mucosa, 5 cm distance from gastric cancer tissue, paracarcinoma tissue and gastric cancer tissue of each specimen. The expression of FasL, P27, PCNA in the above mentioned tissues was analyzed with immunohistochemistry SP method.Results:The expression of FasL was not associated with tumor grade, stage and metastases in lymph nodes. In gastric cancer the expression of PCNA and P27 was correlated with the degree of differentiation, stage and metastases in lymph nodes.Conclusion:FasL may play an important role of immuneprivilege in the development and progression of gastric cancer. P27 may be an important factor to prognosis of gastric cancer. PCNA is an important marker to reflect gastric cancer cell proliferation.
出处
《临床肿瘤学杂志》
CAS
2002年第5期328-330,363,共4页
Chinese Clinical Oncology
