盐酸氟西汀治疗卒中后病理性哭笑

Fluoxetine hydrochloride for patients with poststroke pathological laughing and crying

目的 探讨盐酸氟西汀对卒中后病理性哭笑的治疗作用。方法 前瞻性研究 18例卒中后病理性哭笑病人的临床特点 ,以及盐酸西汀治疗前后病理性哭笑的程度、频率变化。结果 治疗 7d、2周、3周时分别有 6例、8例、8例病人发作完全消失 ;平均每日发作次数迅速减少≥ 5 0 % ,第 2周、第 3周达到高峰 ;治疗过程中病人耐受性好 ,不良反应轻微。结论 盐酸氟西汀治疗病理性哭笑起效快、疗效好、耐受性高。

Objective To investigate the efficacy of fluoxetine hydrochloride(FXT) for patients with poststroke pathological laughing and crying.Methods Eighteen cases of poststroke pathological laughing and crying were given FXT(20～40mg/d).Crying history was determined from semistructured interviews and from diaries kept by the patients or caregivers.Results The number of daily crying(laughing) episodes decreased by at least 50% in all cases 7 days after the treatment with FXT,and 8 patients were free of crying(laughing) episodes 2 weeks after the treatment.The effect was rapid(1～3 days).Severe side-effects related to FXT was not found.Conclusion Fluoxetine hydrochloride plays an important part in treatment of poststroke pathological laughing and crying,which is effective and well-tolerated.