二噁类化合物的生物检测方法研究进展

Research Progress on Bioassay Approaches for Dioxin and Dioxin-like Compounds

二噁英类化合物是一类典型的持久性有机污染物,具有高亲脂性,且稳定性高,能在生物体的多种组织中大量蓄积,并产生致畸致癌致突变等毒性作用,对人类的健康产生极大威胁。二噁英类化合物对生物体的毒性作用主要通过芳香烃受体信号通路介导,二噁英等外源性物质进入细胞后作为配体与胞内的芳香烃受体结合,激活芳香烃受体信号通路,引起一系列的生物效应。根据这一原理,目前已经有很多种生物检测方法应用于二噁英类化合物的检测。该文的主要目的是对目前常用的二噁英类化合物的生物检测方法做一个简单阐述和评价,为后续生物检测方法的改进和完善提供参考。

Dioxin and dioxin-like compounds are typical representatives of persistent organic pollutants(POPs). These com-pounds are highly lipophilic, persistent and accumulated in many tissues of animals. They have the effects of teratogenesis,tumor promotion and mutagenesis which result in toxic effects on human health. The toxic effects of dioxin and dioxin-like compounds are mediated by aryl hydrocarbon receptor(Ah R) signalling pathway. When lipophilic xenobiotic agonists diffuse through the plasma membrane and bind to Ah R, then the Ah R signaling pathway is activated that inducing a serious of bio-logical effects. According to this principle, many bioassay approaches are developed to detect the dioxin and dioxin-like compounds. This review aims to give a description and assessment for bioassay approaches using to detect dioxin and dioxinlike compounds that benefits development of new bioassay techniques.