绒毛膜羊膜炎与早产儿并发症的相关性分析

Analysis on the Relationship between Chorioamniontis and Neonatal Complications of Preterm Infants

目的探讨绒毛膜羊膜炎与早产儿并发症的关系。方法选择在产科分娩的早产儿(≤34周)108例,按是否存在绒毛膜羊膜炎分为绒毛膜羊膜炎组(病例组)50例和非绒毛膜羊膜炎组(对照组)58例,比较2组以下并发症的发病率:窒息、早发型败血症、呼吸窘迫综合征(RDS)、坏死性小肠结肠炎(NEC)、脑室旁白质软化(PVL)、脑室内出血(IVH)、支气管肺发育不良(BPD),分析绒毛膜羊膜炎与上述并发症的相关性。结果病例组窒息、早发型败血症、IVH、PVL、BPD的发病率均高于对照组(P均<0.05);RDS和NEC的发病率2组差别无统计学意义(P>0.05)。结论绒毛膜羊膜炎与早产儿的并发症关系密切,可导致窒息、早发型败血症、PVL、IVH、BPD的发病率升高。

Objective To study the relationship between histological chorioamniontis and complications of premature birth. Methods 108 preterm infants(≤34weeks)were selected from June 2012 to June 2014 in our hospital. The cases were divided into two groups,50 with chorioamnionitis in case group and 58 cases without chorioamnionitis in control group. Clinical and laboratory data of the 108 premature infants were retrospectively analyzed. The complications[asphyxia,neonatal respiratory distress syndrome(RDS),necrotizing entercolitis(NEC),early-onset sepsis,periventricular leukomalacia(PVL),intraventricular hemorrhage(IVH),bronchopulmonary dysplasia(BPD)]of the two groups were compared. The relationship between chorioamniontis and the infants complications were investigated.Results Compared with the control group,the incidence of complications(asphyxia,early-onset sepsis,PVL,IVH,BPD)were higher in the case group,which was with statistical significance(P<0.05). But the incidence of RDS and NEC in the two groups were not statistically significant(P>0.05). Conclusions Chorioamnionitis is associated with the complications of preterm birth. It can increase the incidence of complications(asphyxia,early-onset sepsis,PVL,IVH,BPD)in preterm birth but has little effect on the incidence of the complications RDS and NEC.