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癫痫与抗癫痫药物对围产儿结局的影响

Effects of epilepsy and antiepileptic drugs on perinatal outcome
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摘要 目的研究癫痫和抗癫痫药物(antiepileptic drugs,AEDs)对围产儿结局的影响。方法回顾性分析2008年1月至2016年12月在西安交通大学第一附属医院和第二附属医院妇产科住院分娩的癫痫患者46例作为病例组,按1∶4比例收集同期分娩的非癫痫孕妇184例作为对照组。分析癫痫和AEDs对围产儿结局的影响。结果根据孕期是否服用AEDs分为服药亚组(23例)和未服药亚组(23例),未服药亚组教育水平和规律产检率低;单因素分析显示;未服药亚组发生与对照组相比发生围产儿不良结局风险,有统计学差异(c OR=6.18,95%CI[2.49~15.31]);多因素回归模型校正混杂因素后显示未服药亚组发生围产儿不良结局是对照组的4.92(1.81~13.37)倍。结论癫痫患者发生围产儿不良结局的风险增加,这种风险在未服药亚组中更为突出。 Objective To investigate the effects of epilepsy and antiepileptic drugs(AEDs)on perinatal outcome.Methods 46 cases of pregnant women with epilepsy who gave birth at the First Affiliated Hospital and Second Affiliated Hospital of Xi’an Jiaotong University from January 2008 to December 2016 were analyzed retrospectively as the study group.As a proportion of 1:4,184 normal pregnant women were collected as the control group druing the same period.The effects of epilepsy and AEDs on perinatal outcome were analyzed statistically.Results Among the study group,23 cases(23/46)didn’t use AEDs during pregnancy.And they had low education level and rate of regular perinatal examination.Single factor analysis showed that the epileptic women who didn’t use AEDs during pregnancy were more likely to have adverse perinatal outcome(cOR=6.18,95%CI[2.49~15.31]).Using the multiple factor model to adjust confounding factors,the results showed the adverse perinatal outcome for the epileptic women who didn’t use AEDs during pregnancy were 4.92(1.81~13.37)times than the control group.Conclusion Pregnant women with epilepsy have higher risk of adverse perinatal outcomes,and even more obvious in the patients who didn’t use AEDs during pregnancy.
作者 李倩倩 原婷 王艳艳 李雪兰 韩蓁 LI Qianqian;YUAN Ting;WANG Yanyan;LI xuelan;HAN Zhen(Department of Obstetrics Gynecology,First Affiliated Hospital of Xi'an Jiaotong University College of Medicine,Xi'an 710061,China)
出处 《中国妇产科临床杂志》 CSCD 北大核心 2019年第5期404-406,共3页 Chinese Journal of Clinical Obstetrics and Gynecology
关键词 妊娠合并癫痫 抗癫痫药物 围产儿结局 pregnancy with epilepsy antiepileptic drugs perinatal outcome
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