米索前列醇用于晚期妊娠引产的临床观察

A COMPARISON OF MISOPROSTOL AND PROSTAGLANDIN E_2 GEL FOR CERVICAL RIPENING AND INDUCTION OF LABOUR

目的 :探讨米索前列醇 ( MP)阴道放药对晚期妊娠引产的效果和安全性。方法 :89名晚期妊娠妇女随机分成两组在阴道放药途径下 ,一组给予MP1 0 0μg;另一组给予前列腺素 E2 凝胶 ( PGE2 gel) 1 mg;6h后如未临产给予静点催产素。结果 :6h后两组宫颈评分增加 ;引产至分娩时间 ,催产素使用率 MP组显著短于 PGE2 ( P<0 .0 5) ;2 4 h分娩率 MP组显著高于 PGE2 ( P<0 .0 5)组 ;子宫过度刺激综合症发生率两组之间差别无统计意义。结论 :阴道内放置 MP片用于晚期妊娠宫颈成熟和引产效果优于 PGE2 gel。

To determine the effect and safety of intravaginal misoprostol(MP) for labour induction Methods:89 late pregnant women were randomized to receive either MP100μg or prostaglandin E 2gel(PGE 2)1mg intravaginally Six hour later,patients were given oxytoxin if they were not in labour Results:The interval of induction to delivery and the need for oxytoxin was of subjects receiving significantly shorter and delivery by 24h was signifticantly longer MP than that of women receiving PGE 2 gel.There was no difference in the incidence of uterus hyperstimulation between the two groups Conclus ion:MP is more effective than PGE 2gel and whats more it won't increase side effects in intravaginal administration for cervical ripening and labour induction