碰撞癌7例临床及病理分析

Clinical and pathological analysis of collision carcinoma: report of 7 patients

目的 探讨碰撞癌的流行病学、病理和临床特点。 方法 回顾性分析 7例碰撞癌的临床资料并结合文献复习 ,总结其患病率、高发年龄、性别比、好发部位、临床表现、治疗手段、病理特点等。 结果 碰撞癌罕见 ,高发年龄大于 65岁 ,男性高发 ;好发部位为胃、肝脏、贲门、子宫、肺等 ,临床表现无特殊、术前多不能明确诊断、术后病理诊断是唯一的确诊方法 ;治疗以手术为主、辅以化疗或放疗 ;病理特点为同一宿主同一部位或器官 2个不同类型肿瘤的结合、瘤组织间没有移行和混合 ,有各自的转移途径。碰撞癌以鳞癌和腺癌的碰撞为主。 结论 碰撞癌是一种罕见的恶性肿瘤结合 。

Objective To study the epidemiological,pathological,clinical features and therapy of collision carcinoma. Methods Seven patients were studied retrospectively against the background of the literature from 1980 to 2001, including the incidence,age of onset,sex ratio,predilection sites, clinial signs, pathological features and therapies. Results Collision carcinoma is rare, but more common in males than in females. The peak onset age is more than 65 years. It is found freguantly in the stomach,liver,uterine,esophagogastric junction, and lung. Without special clinical features, it is difficult to diagnose. Pathological findings are the only way to make a correct diagnosis before operation. Operation is the major therapy, assisted by chemotherapy or/and radiotherapy when necessary. Collision carcinoma represents a coexistence of two adjacent but histologically different malignant neoplasmas without histological admixture in an organ. Conclusions Collision carcinoma is rare but composed of mosaics of two malignant tumours. The clinical features of collision carcinoma need further investigation.