卡马西平硬脂酸固体脂质纳米粒的制备与理化性质研究

Preparation and Physicochemical Properties of Carbamazepine Loaded Stearic Acid Solid Lipid Nanoparticles

用乳化 -溶剂挥发法制得卡马西平硬脂酸纳米粒 ,并对其粒径、形态、表面电位、包封率、体外释药性质等进行研究。得到的硬脂酸纳米粒平均粒径 (D50 ) 12 0 .0± 9.8nm,Zeta电位为 - 5 0 .6± 3.3m V,包封率 89.8% ,药物体外释放符合 Higuchi线性方程 。

Carbamazepine loaded stearic acid solid lipid nanoparicles(SLN) were prepared, and its particle size, morphology, zeta potential, entrapment efficiency and drug release in vitro were studied. The stearic acid SLN was prepared by the procedure of emulsification and solvent evaporation. The characteristic data showed that the volume mean diameter ( D 50 ) of the SLN was 120±9.8 nm,zeta potential was -50.6±3.3 mV,average entrapment efficiency was 89.8% and drug release profiles in vitro were in accordance with Higuchi equation and exhibited obvious sustained release effects.