手术对晚期卵巢癌患者机体免疫功能的影响

EFFECT OF SURGERY ON THE IMMUNE FUNCTION OF THE PATIENTS WITH ADVANCED OVARIAN CANCER

本文对12例晚期卵巢癌患者术前、术后的免疫功能分别进行了研究,以15例健康女性为对照。结果表明,卵巢癌患者的天然杀伤细胞活性及 T辅助细胞减低,T 抑制细胞增多,T 辅助细胞与 T 抑制细胞比值下降,与对照组相比,差别具有显著性。经瘤细胞减灭术后,机体免疫功能有不同程度的恢复,但总 T 淋巴细胞改变不明显。

The cytotoxic activity of natural killer cells(NK) and T—lymphocyte subsets in peripheral blood were studied in 12 patients with advanced ovarian cancer before and after surgery,with 15 healthy females as controls.In cancer group,the cytotoxic activity of NK cells, OKT_4 cells and OKT_4/OKT_8 cells ratio were lower,but OKT_8 cells were significantly increased. After turnout cytoreductive operation,the immune function of the cancer patients was increased significantly.No significant difference was found in OKT_3 cells after operation.