原发性巨球蛋白血症14例临床分析

Clinical analysis of 14 patients with Waldenstrm Macroglobulinemia

目的探讨原发性巨球蛋白血症(WM)的临床特点。方法对14例WM患者进行回顾性分析。结果11例接受治疗的患者完全缓解3例,部分缓解4例。7例存活,病程最长达10.5年。结论WM是不能治愈性疾病,但经积极治疗生存期可延长。WM伴有血粘滞性增高者预后不佳,化疗及血浆分离术后可获长期生存。

ObjectiveTo investigate the diagnosis and treatment of Waldenstrm Macroglobulinemia. MethodsThe clinicalinformation of 14 patients with Waldenstrm Macroglobulinemia were analyzed retrospectively. Results3 cases had achievedcomplete response(CR). 4 cases had achieved partial response(PR). 7 cases remained alive with event-free survival, one of thembeyonded 10.5 years. Conclusions The feasibility of the combination agent appears highly active and safe in the management ofWM.