抗肿瘤新药——依西美坦的合成工艺研究

A study on the synthesis of a new antitumor drug-Exemestane

目的 :改进抗肿瘤新药———依西美坦的合成方法。方法 :以去氢表雄酮为原料 ,经沃氏氧化、亚甲基化和脱氢而得。结果 :合成产物的化学结构经元素分析、红外光谱、核磁共振和质谱等确证。结论

OBJECTIVE:To modify the synthetic method of the new antitumor drug-Exemestane. METHOD:Exemestane was synthesized by steps of Oppenauer oxidation, methylenation and dehydrogenation, starting from 5-Epiandrostane-17-one. RESULTS:The chemical structure of synthetic product was confirmed by element analysis, IR, 1HNMR and MS.CONCLUSION:This synthetic route is practical.