丹参联合缺血预适应对缺血性心肌损伤的保护作用

Salvia Miltiorrhiza Enhances the Cardioprotective Effects of Ischemic Preconditioning in the Rat

目的 :研究丹参 (SM)联合缺血预适应 (IP)对缺血性心肌损伤的保护作用 .方法 :以整体麻醉SD大鼠心脏冠状动脉左前降支结扎 /松开作为缺血 /再灌注动物模型 ,观察对心律失常程度和心肌梗塞范围的影响。结果 :IP能减轻复灌性心律失常的严重程度 ,缩小心肌梗塞范围 ;SM能缩小心肌梗塞范围 ;SM联合IP与单纯IP比较 ,心肌梗塞范围进一步缩小 ;SM联合IP与单纯SM比较 ,心律失常严重程度和心肌梗塞面积均进一步减小。结论

OBJECTIVE:To investigate the effect of salvia miltiorrhiza (SM) on the cardioprotection of ischemic preconditioning (IP) in the anaesthetized rat. METHOD:Sprague-Dawley rats were used. The left anterior descending artery was ligated as ischemia. Reperfusion induced arrhythmias and infarct size were measured. RESULTS:IP reduced the severity of reperfusion-induced arrhythmias and limited the infarct size and SM limited the infarct size. SM plus IP significantly reduced the infarct size compared with IP that was used alone and significantly decreased both the infarct size and the severity of reperfusion-induced arrhythmias when compared with SM alone.CONCLUSION:The results suggest that SM will enhance the cardioprotective effects of IP.