α-细辛醚贴剂的家兔相对生物利用度研究

The relative bioavailability of α-asarum patch on rabbit

目的 :测定α-细辛醚凝胶贴剂在家兔体内的相对生物利用度。方法 :家兔口服和透皮贴剂交叉试验 ,分别测定血药浓度和AUC ,采用 3P97软件中的统计程序计算生物利用度。结果 :家兔体内生物利用度试验表明 ,α -细辛醚贴剂的生物利用度明显高于胶囊剂 ,贴剂与胶囊剂相对生物利用度为 116 7.6 %。结论 :由于α -细辛醚的生物利用度很低 ,只有 2 .75 - 5 % ,因此 ,我们制备了α-细辛醚贴剂 ,实验结果表明 ,贴剂的生物利用度明显提高 ,α -细辛醚贴剂这一剂型对α

OBJECTIVE:To determine the relative bioavailability of α-asarum patch in vivo on rabbit to prove the feasibility of α-asarum patch. METHOD:A crossover test is used on rabbit with oral administration and dermal patch.Drug concentration in blood and AUC are determined respectively, then to figure out the relative bioavailability ofα-asarum patch.RESULTS:The relative bioavailability of α-asarum patch test prove that the bioavailability of α-asarum patch is obviously superior to capsule. The relative bioavailability of α-asarum patch and capsule is 1167.6%. CONCLUSION:Because the bioavailability of α-asarum in oral administration is about 2.75 % to5%, we prepare the α-asarum patch.The test results prove that the dermal patch can enhance the bioavailability ofα-asarum.