西比灵合用妥泰预防偏头痛发作的临床研究

A Clinical Study of Sibelium Combining Topiramate in Prophylactic Treatment of Migraine

目的 :观察西比灵合用妥泰对偏头痛发作的预防作用。方法 :将 12 6例偏头痛患者随机分为西比灵合用妥泰组 (4 2例 )、西比灵组 (4 4例 )及心得安组 (4 0例 ) ,疗程 1月 ,观察 3月 ,观察上述三组治疗前后头痛指数和一月内头痛总天数的变化。结果 :西比灵合用妥泰组和西比灵组头痛指数及一月内头痛总天数皆较心得安组显著降低 ,而西比灵合用妥泰组较西比灵组明显降低。结论

OBJECTIVE:To observe the effect of sibelium combining topiramate (TPM) in migraine prevention. METHOD:In this study, 126 patients with migraine was included and was divided into sibelium combining TPM group(42 cases), sibelium group(44 cases) and propranolol group(40 cases).All groups were treated for 1 month. The headache index and headache days in one month of all groups before and after treatment were observed.RESULTS:The headache index and headache days in one month of sibelium combining TPM group and sibelium group were significantly declined compared with those of propranolol group, and those of sibelium combining TPM group were significant declined compared with those of sibelium group.CONCLUSION:Sibelium combining TPM plays a better role in migraine prevention.