盐酸西替利嗪片的溶出度考察

Study on the dissolution rate of cetirizine hydrochloride tablets

目的 对盐酸西替利嗪片进行溶出度测定 ,以考察其质量。方法 采用紫外分光光度法测定了盐酸西替利嗪片的溶出度 ,线性范围为 2～ 4 0 mg· L-1(r =0 .9999)。结果 自制品与国外同种产品比较 ,溶出参数T50 、Td、m无显著性差异。结论 自制品溶出度较好。

Objective To determine dissolution of cetirizine hydrochloride tablets and investigate its quality. Method The dissolution of cetirizine hydrochloride tablets was detemined by UV. The linear range of concentration was from 2 to 40 mg·L -1(r=0.999 9, n=6). Results The comparison of two kinds of tablets showed that the coefficients(T 50?T d?m) of dissolution parameters in water of(37±0.5)℃ had no significant difference. Conclusion The dissolution of our cetirizine hydrochloride tablets is good.