多奈哌齐治疗脑卒中后基底节性失语症的疗效观察

Clinical Observation on Basal Ganglia Aphasia after Stroke Treated by Donepezil

目的:评价多奈哌齐治疗脑卒中后基底节性失语症的疗效。方法:37例患者随机分为多奈哌齐组(治疗组)19例和常规治疗组(对照组)18例。对照组用常规营养神经药物和言语训练,每天1次,每次30 min;治疗组在对照组基础上加用多奈哌齐片,每次5 mg,每天1次。连续治疗8周后采用简易精神状态评价量表(MMSE)、波士顿诊断性失语检查法(BDAE)及西部失语症检查量表(WAB)评定疗效。结果:治疗后2组患者MMSE、BDAE及WAB评分比较,治疗组优于对照组(P<0.05)。且该药不良反应轻微,患者易接受。结论:多奈哌齐治疗脑卒中后基底节性失语症安全有效。

Objective:To evaluate the curative effect of donepezil on basal ganglia aphasia after stroke. Methods:A total of 37 patients with basal ganglia aphasia after stroke were randomly assigned to donepezil group(n=19) and control group(n=18). Control group was treated with neural nutrition medicine and speech training for 30 minutes each day. Donepezil group received donepezil at a dose of 5 mg each time additionally,and one time daily. After eight weeks,the MMSE,BDAE and WAB scales were used to evaluate the curative effect before and after the treatment. Results:There was a significant difference in the MMSE,BDAE and WAB scales between the control group and the donepezil group after eight weeks. The curative effect of donepezil group was better than that of control group with mild side reactions and good dependence. Conclusion:Donepezil is safe and effective for the treatment of basal ganglia aphasia after stroke.