狼疮带试验对诊断系统性红斑狼疮的意义

Diagnostic significance of the lupus band test in systemic lupus erythematosus

目的 探讨狼疮带试验 (LBT)在系统性红斑狼疮 (SLE)诊断中的意义。方法 :对 15 0例SLE患者和 5 0例非SLE患者分别检测血清ANA、ds-DNA、补体、免疫球蛋白、尿素氮、肌酐、尿蛋白定性及定量、肾脏组织病理、LBT免疫成分。结果 LBT在SLE诊断中的敏感性为 71%、特异性为 84 %、阳性预测值为 93%、阴性预测值为 4 8% ,LBT阳性与肾损害及狼疮活动关系密切。

Objective To investigate the diagnostic significance of the lupus band test in systemic lupus erythematosus. Methods 150 patients with SLE and 50 patients without SLE were detected serum antinuclear antibody, ds-DNA, complement, immunoglobulin blood urea nitrogen, Serum creatinine, urine albumin, 24-hour urine protein, kidney histopathology, immune composition in the LBT. Result In SLE, the sensitivity of the LBT was 71%, and the specificity 84%. The positive predictive value was 93%, and negative predictive value was 48%. LBT positive is closely connected with kidney lesion and activity of lupus erythematosus. Conclusion LBT is a important auxiliary diagnostic target in SLE.