新型钴、镍共晶化合物的合成、结构及生物活性研究

New cobalt/nickel co-crystal compounds:synthesis,crystal structure and vitro antitumor activity study

以4-(N,N′-双(4-羧基苄基)氨基)苯磺酸和邻菲罗啉为原料,分别与乙酸钴、乙酸镍反应,经水热法合成了2种新型共晶化合物{[Co(phen)2(H_2O)_2]·(HL)·(H_2O)_2}(1)和{[Ni(phen)2(H_2O)_2]·(HL)·(H_2O)_5}(2)(H3L=4-(N,N′-双(4-羧基苄基)氨基)苯磺酸,phen=邻菲罗啉),其结构通过单晶X-射线衍射、元素分析、XRD粉末衍射分析和红外光谱分析等进行了表征.采用MTT法测试了化合物1和2对人肝癌细胞HepG2、人肺癌细胞NCI-H460、胃癌细胞株MGC80-3、肝癌细胞株BEL-7404和正常肝细胞株HL-7702增殖抑制活性.结果表明化合物1对HepG2,MGC80-3和BEL-7404表现出较好的抑制活性并且均优于顺铂的抑制活性;化合物2对MGC80-3表现出较好的抑制活性且优于顺铂的抑制活性.

Two new co-crystal compounds{[Co(phen)2(H2O)2]·(HL)·(H2O)2}(1)and{[Ni(phen)2(H2O)2]·(HL)·(H2O)5}(2)(H3 L=4-(N,N′-bis(4-carboxybenzyl)amino)benzene-sulfonic acid,phen=phenanthroline)have been synthesized through hydro-thermally method and been characterized by IR,X-ray powder diffraction,elemental analysis(CHN)and single-crystal X-ray diffraction.The compounds 1 and 2 are crystallized in the monoclinic system,with space group P21/c.The metal ions are six coordinated by two O atoms from water molecules and four N atoms from two different phenanthroline,which form an octahedral geometry,respectively.The ligand HL2-acts as a counterbalance to anion in compounds 1 and 2.Vitro antitumor activity studies of ligands and compounds 1 and 2 also indicate that they possess an anticancer property.