eIF4E和ki67在子宫内膜异位症中的表达及其临床意义

The Ex Pression and clinical significance of eIF4E and ki67 in patients with endometrosis

目的探讨e IF4E和ki67在子宫内膜异位症中的表达及临床意义。方法采用免疫组化技术SP法检测异位内膜组(30例),在位内膜组(30例)及正常内膜组(20例)中e IF4E及ki67蛋白的表达水平。结果 e IF4E和ki67在3组内膜中表达强弱依次为异位内膜>在位内膜>正常内膜,其差异有显著统计学意义(P<0.01);e IF4E在正常内膜组和在位内膜中分泌期高于增殖期,其差异有显著统计学意义(P<0.05),ki67在正常内膜组分泌期高于增殖期(P<0.05),在位内膜组增殖期高于分泌物(P<0.05);而e IF4E和ki67两者在异位内膜和在位内膜中的表达呈正相关(r=0.861,P<0.01;r=0.788,P<0.01),在正常内膜表达无明显相关性(r=0.297,P=0.207)。结论 eIF4E和ki67在子宫内膜异位症表达明显增高,e IF4E和ki67可能与子宫内膜异位症发生发展密切相关。

Objective To explore the expression and clinical significance of e IF4 E and ki67 in endometriosis. Methods The expression of e IF4 E and ki67 were detected by immuno- histochemical method of SP in 30 cases of endometriosis and 20 cases of normal endometrium. Results Expression of the three groups showed such sequence as follows about e IF4 E and ki67:ectopic endometrium>eutopic endometrium>normal endometrium, there was a significant difference statistically(P<0.01);e IF4 E during the reign of normal endometrium and endometrial secretion period is higher than the proliferation period, the differences are significant statistical significance(P<0.05), ki67 in normal secretory phase endometrium group is higher than breeding period(P<0.05), in ectopic group multiplication period is higher than the discharge(P<0.05). The e IF4 E and ki67 protein had obvious positive correlation in ectopic endometrial and endometrium(r=0.861, P<0.01; r=0.788, P<0.01), but there was no correlation in the normal endometrium(r=0.297, P=0.207). Conclusion e IF4 E and ki67 in endometriosis express obviously increased. The expression of e IF4 E and ki67 were positively associated with development and progression of endometriosis.