摘要
纤毛广泛存在于体内的细胞表面,其中"9+0"型纤毛又被称为原纤毛。纤毛在机体发育和调节过程中必不可少,与许多疾病的发病有关,尤其是骨方面。本文就纤毛和原纤毛的结构、调控、作用,及原纤毛在骨发育、骨相关细胞中作用和原纤毛相关骨疾病进行综述。
出处
《分子影像学杂志》
2015年第1期8-12,共5页
Journal of Molecular Imaging
基金
教育部博士点基金(20125503120015)
重庆市自然科学基金(cstc2014jcyj A0024)
参考文献20
-
1C.L. Thompson,J.P. Chapple,M.M. Knight.Primary cilia disassembly down regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes[J]. Osteoarthritis and Cartilage . 2013
-
2Miriam Schmidts,Julia Vodopiutz,Sonia Christou-Savina,Claudio R. Cortés,Aideen M. McInerney-Leo,Richard D. Emes,Heleen H. Arts,Beyhan Tüysüz,Jason D’Silva,Paul J. Leo,Tom C. Giles,Machteld M. Oud,Jessica A. Harris,Marije Koopmans,Mhairi Marshall,Nursel El?ioglu,Alma Kuechler,Detlef Bockenhauer,Anthony T. Moore,Louise C. Wilson,Andreas R. Janecke,Matthew E. Hurles,Warren Emmet,Brooke Gardiner,Berthold Streubel,Belinda Dopita,Andreas Zankl,Hülya Kayserili,Peter J. Scambler,Matthew.Mutations in the Gene Encoding IFT Dynein Complex Component WDR34 Cause Jeune Asphyxiating Thoracic Dystrophy[J]. The American Journal of Human Genetics . 2013 (5)
-
3Changdong Wang,Xue Yuan,Shuying Yang.IFT80 is essential for chondrocyte differentiation by regulating Hedgehog and Wnt signaling pathways[J]. Experimental Cell Research . 2013 (5)
-
4Miriam Schmidts,Valeska Frank,Tobias Eisenberger,Saeed al Turki,Albane A. Bizet,Dinu Antony,Suzanne Rix,Christian Decker,Nadine Bachmann,Martin Bald,Tobias Vinke,Burkhard Toenshoff,Natalia Di Donato,Theresa Neuhann,Jane L. Hartley,Eamonn R. Maher,Radovan Bogdanovi?,Amira Peco‐Anti?,Christoph Mache,Matthew E. Hurles,Ivana Joksi?,Marija Gu?‐??eki?,Jelena Dobricic,Mirjana Brankovic‐Magic,Hanno J. Bolz,Gregory J. Pazour,Philip L. Beales,Peter J. Scambler,Sophie Saunier,Hannah M. M.Combined NGS Approaches Identify Mutations in the Intraflagellar Transport Gene IFT140 in Skeletal Ciliopathies with Early Progressive Kidney Disease[J]. Human Mutation . 2013 (5)
-
5David A. Hoey,Shane Tormey,Stacy Ramcharan,Fergal J. O’Brien,Christopher R. Jacobs.Primary Cilia‐Mediated Mechanotransduction in Human Mesenchymal Stem Cells[J]. STEM CELLS . 2012 (11)
-
6Ellen J. Ezratty,Nicole Stokes,Sophia Chai,Alok S. Shah,Scott E. Williams,Elaine Fuchs.A Role for the Primary Cilium in Notch Signaling and Epidermal Differentiation during Skin Development[J]. Cell . 2011 (7)
-
7David A. Hoey,Daniel J. Kelly,Christopher R. Jacobs.A role for the primary cilium in paracrine signaling between mechanically stimulated osteocytes and mesenchymal stem cells[J]. Biochemical and Biophysical Research Communications . 2011 (1)
-
8Minna Luo,Muqing Cao,Yinan Kan,Guihua Li,William Snell,Junmin Pan.The Phosphorylation State of an Aurora-Like Kinase Marks the Length of Growing Flagella in Chlamydomonas[J]. Current Biology . 2011 (7)
-
9C.-F. Chang,G. Ramaswamy,R. Serra.Depletion of primary cilia in articular chondrocytes results in reduced Gli3 repressor to activator ratio, increased Hedgehog signaling, and symptoms of early osteoarthritis[J]. Osteoarthritis and Cartilage . 2011 (2)
-
10David A. Hoey,Matthew E. Downs,Christopher R. Jacobs.The mechanics of the primary cilium: An intricate structure with complex function[J]. Journal of Biomechanics . 2011 (1)
同被引文献5
-
1姜容,刘贵勇,陈鹏,汪长东.IFT20蛋白在不同肿瘤组织中表达的研究[J].中国肿瘤临床,2012,29(12):841-843. 被引量：8
-
2邓小燕,李飞龙,胡宁,潘嘉川,汪长东.IFT80蛋白对肿瘤影响的研究[J].中国肿瘤临床,2014,41(23):1527-1531. 被引量：1
-
3刘革力,李飞龙,胡宁,潘嘉川,汪长东.IFT20蛋白在肺癌组织中的表达及其对肺癌A549细胞增殖的影响[J].肿瘤,2015,35(6):666-674. 被引量：1
-
4辛红美,许洁,汪长东.淫羊藿苷促进MC3T3-E1成骨分化通过Hedgehog信号通路[J].中国药理学通报,2020,36(5):616-620. 被引量：21
-
5Neil A.Duldulao,Jade Li,Zhaoxia Sun.Cilia in cell signaling and human disorders[J].Protein & Cell,2010,1(8):726-736. 被引量：2
-
1刘洪斌.肝内胆管上皮细胞原纤毛结构研究进展[J].中国中西医结合外科杂志,2009,15(2):199-200.
-
2江永娣,陈楠,王朝晖,付秀兰,董德长,郑丽叶,储谦.结节病的肾损害病例报告并文献复习[J].老年医学与保健,1998,4(1):24-26.
-
3王华贝.OPG/RANKL/RANK轴在骨相关疾病中的研究现状[J].中国临床研究,2012,25(1):80-81. 被引量：3
-
4燕晓宇,罗从风,曾炳芳.体外震波对骨和骨疾病的作用及其机制[J].临床骨科杂志,2007,10(6):566-569.
-
5郭伟,王麓山.骨保护素在骨相关疾病领域的研究进展[J].中国矫形外科杂志,2013,21(24):2499-2502. 被引量：2
-
6朱长谋,王洪.蛋白酶与骨关节炎软骨退变[J].国际骨科学杂志,2007,28(1):30-32. 被引量：5
-
7周达梅,陈盼盼,杨敏,朱四海,陈爽.儿童全麻插管术后复苏期的气道管理[J].江苏医药,2015,41(2):227-228. 被引量：4
-
8赵长清,王利民.细胞凋亡与椎间盘退变[J].华北煤炭医学院学报,2005,7(2):169-171. 被引量：4
-
9张蕊,汪涛,刘大海,王代文,骆艳杰.表皮生长因子与皮肤软组织扩张器联合治疗体表瘢痕[J].西南军医,2009,11(2):177-179. 被引量：6
-
10郭英俊,聂林,张皓轩.ASICs在骨相关疾病中的表达、功能变化及意义[J].山东医药,2013,53(19):85-87.
